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Valinomycin

Cat. No. M8842
Valinomycin Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Chemical Information
Molecular Weight 1111.32
Formula C54H90N6O18
CAS Number 2001-95-8
Form Solid
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daniel J Watson, et al. Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin

[2] ZhangFei Su, et al. Ion-Pairing Mechanism for the Valinomycin-Mediated Transport of Potassium Ions across Phospholipid Bilayers

[3] Dong Zhang, et al. Valinomycin as a potential antiviral agent against coronaviruses: A review

[4] Jiř Czernek, et al. Polymorphic Forms of Valinomycin Investigated by NMR Crystallography

[5] Magdalena Anna Kroteń, et al. Cereulide and valinomycin, two important natural dodecadepsipeptides with ionophoretic activities

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