Vaccarin is an active flavonoid glycoside with a variety of biological functions. Vaccarin significantly promoted wound healing and proliferation of endothelial and fibroblast cells at the wound site. Vaccarin improves insulin resistance and steatosis by activating the AMPK signaling pathway.
Molecular Weight | 726.63 |
Formula | C32H38O19 |
CAS Number | 53452-16-7 |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage | 4°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Jiang-Nan Sun, et al. Vaccarin enhances intestinal barrier function in type 2 diabetic mice
Related AMPK Products |
---|
SAMS
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK). |
Marein
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. |
Malvidin-3-O-arabinoside chloride
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. |
AMPK activator 12
AMPK activator 12 is a potent AMPK activator and GDF15 inducer. |
Kazinol U
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.