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Urolithin C

Cat. No. M11316
Urolithin C Structure
Size Price Availability Quantity
10mg USD 100  USD100 In stock
50mg USD 280  USD280 In stock
100mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

Urolithin C, a polyphenol intestinal microbial metabolite of ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is an L-type Ca2+ channel opening agent that enhances Ca2+ influx. Urolithin C induces apoptosis and stimulates the formation of reactive oxygen species (ROS) through mitochondria mediated pathway.

Chemical Information
Molecular Weight 244.2
Formula C13H8O5
CAS Number 165393-06-6
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Francesco Crudo, et al. Toxicol Lett. An in vitro study on the transport and phase II metabolism of the mycotoxin alternariol in combination with the structurally related gut microbial metabolite urolithin C

[2] Slimane Toubal, et al. Fundam Clin Pharmacol. Urolithin C increases glucose-induced ERK activation which contributes to insulin secretion

[3] Hiroko Watanabe, et al. J Biosci Bioeng. Evaluation of electron-transferring cofactor mediating enzyme systems involved in urolithin dehydroxylation in Gordonibacter urolithinfaciens DSM 27213

[4] Morgane Bayle, et al. Br J Pharmacol. The ellagitannin metabolite urolithin C is a glucose-dependent regulator of insulin secretion through activation of L-type calcium channels

[5] Inhae Kang, et al. Mol Nutr Food Res. Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

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