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Uricase

Cat. No. M10640
Uricase Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Uricase is a new type of uric acid-lowering compound, also known as Urate Oxidase, it is characterized by promoting the decomposition of uric acid, catalyzes the rapid oxidation of uric acid into allantoic acid, which is no longer reabsorbed and excreted by the renal tubules, thereby reducing the content of uric acid in the plasma.

Chemical Information
Molecular Weight 567.40
Formula C18H26N5O14P
CAS Number 9002-12-4
Solubility (25°C) Slightly soluble in alkaline buffer
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nan Fan, et al. PLoS One. Uricase deficiency causes mild and multiple organ injuries in rats

[2] Xiuting Hu, et al. Int J Biol Macromol. Dextrin-uricase conjugate: Preparation, characterization, and enzymatic properties

[3] James T Kratzer, et al. Proc Natl Acad Sci U S A. Evolutionary history and metabolic insights of ancient mammalian uricases

[4] Merry R Sherman, et al. Adv Drug Deliv Rev. PEG-uricase in the management of treatment-resistant gout and hyperuricemia

[5] P A Simkin, et al. N Engl J Med. Monkey uricase

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