Uricase is a new type of uric acid-lowering compound, also known as Urate Oxidase, it is characterized by promoting the decomposition of uric acid, catalyzes the rapid oxidation of uric acid into allantoic acid, which is no longer reabsorbed and excreted by the renal tubules, thereby reducing the content of uric acid in the plasma.
Molecular Weight | 567.40 |
Formula | C18H26N5O14P |
CAS Number | 9002-12-4 |
Solubility (25°C) | Slightly soluble in alkaline buffer |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Nan Fan, et al. PLoS One. Uricase deficiency causes mild and multiple organ injuries in rats
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