Uric acid is a scavenger of oxygen radical, a very important antioxidant and a product of the metabolic decomposition of purine nucleotides. Helps maintain stable blood pressure and fights oxidative stress. Uric acid removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite and inhibits lipid peroxidation. It can be used to induce animal models of uric acid nephropathy.
| Molecular Weight | 168.11 |
| Formula | C5H4N4O3 |
| CAS Number | 69-93-2 |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Qiangwei Wang, et al. Crit Rev Anal Chem. Recent Progress on Uric Acid Detection: A Review
[4] Sahar A Fathallah-Shaykh, et al. Pediatr Nephrol. Uric acid and the kidney
[5] Daniel I Feig, et al. Curr Hypertens Rep. Uric acid and hypertension
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