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Uprosertib (GSK2141795)

Cat. No. M6044
Uprosertib (GSK2141795) Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 180 In stock
50mg USD 600 In stock
100mg USD 880 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 429.25
Formula C18H16Cl2F2N4O2
CAS Number 1047634-65-0
Purity >99%
Solubility 36 mg/mL in DMSO
Storage at -20°C
References

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.
Cheraghchi-Bashi A, et al. Oncotarget. 2015 Dec 8;6(39):41736-49. PMID: 26497682.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Uprosertib (GSK2141795) supplier, Akt, inhibitors

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