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Uniconazole

Cat. No. M11149
Uniconazole  Structure
Size Price Availability Quantity
500mg USD 70  USD70 In stock
1g USD 120  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 291.78
Formula C15H18ClN3O
CAS Number 83657-22-1
Purity >98%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C
References

[1] Dong Guo, et al. Pestic Biochem Physiol. Stereochemistry of chiral pesticide uniconazole and enantioselective metabolism in rat liver microsomes

[2] Hang Zhou, et al. Ecotoxicol Environ Saf. Effect of uniconazole to soybean seed priming treatment under drought stress at VC stage

[3] Ying Jiang, et al. Sci Rep. Physiological and transcriptome analyses for assessing the effects of exogenous uniconazole on drought tolerance in hemp (Cannabis sativa L.)

[4] I Ahmad, et al. Plant Biol (Stuttg). Effect of uniconazole and nitrogen level on lodging resistance and yield potential of maize under medium and high plant density

[5] Irshad Ahmad, et al. Protoplasma. Hormonal changes with uniconazole trigger canopy apparent photosynthesis and grain filling in wheat crop in a semi-arid climate

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  Catalog
Abmole Inhibitor Catalog




Keywords: Uniconazole supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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