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UKI-1

Cat. No. M9255
UKI-1 Structure
Size Price Availability Quantity
5mg USD 400 In stock
10mg USD 600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator, which inhibits the invasive capacity of carcinoma cells with a Ki of 0.41 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 613.81
Formula C32H47N5O5S
CAS Number 220355-63-5
Purity >98%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system.
Ertongur S, et al. Int J Cancer. 2004 Jul 20;110(6):815-24. PMID: 15170662.

Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based dr ug design.
Zeslawska E, et al. J Mol Biol. 2000 Aug 11;301(2):465-75. PMID: 10926521.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: UKI-1 supplier, inhibitors

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