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UBP302

Cat. No. M8838
UBP302 Structure
Size Price Availability
1mg USD 245  USD245 3-4 Weeks
5mg USD 625  USD625 3-4 Weeks
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Quality Control & Documentation
Biological Activity

UBP302 is a selective GluR5 antagonist. UBP302 is the active enantiomer of UB296 and is one of the most potent GluR5 antagonists available for research use.

Chemical Information
Molecular Weight 333.3
Formula C15H15N3O6
CAS Number 745055-91-8
Solubility (25°C) DMSO: ≥5 mg/mL at 60 °C (with warming for 5 minutes)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] James P Apland, et al. The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302

[2] V Aroniadou-Anderjaska, et al. Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors

[3] Jonathan Weng-Thim Ho, et al. Contributions of area Te2 to rat recognition memory

[4] Mark L Mayer, et al. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists

[5] Julia C A More, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist

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