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Ubenimex

Cat. No. M1883
Ubenimex Structure
Synonym:

Bestatin

Size Price Availability Quantity
10mg USD 80  USD80 In stock
50mg USD 215  USD215 In stock
100mg USD 360  USD360 In stock
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Quality Control
Biological Activity

Ubenimex (Bestatin) is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N (Ki = 0.001 - 90 mM). Ubenimex inhibits enkephalin metabolism and leukotriene A4 hydrolase. Bestatin also inhibits tumor cell proliferation. Bestatin induced cell growth inhibition and phenotypic changes of HL-60 and HL-60R cell lines. In vitro, the upregulation of CD13/aminopeptidase N was found after 1 hr, however, the downregulation was observed after 3 hrs incubation with Ubenimex (Bestatin). On the other hand, the downregulation of CD15 and CD33 was observed after both one and 3 hrs incubation. Ubenimex may also be an effective anti-leukemic agent in vivo.

Product Citations
Customer Product Validations & Biological Datas
Source Nan Fang Yi Ke Da Xue Xue Bao (2020 Oct), Figure 3, Ubenimex (Abmole Bioscience)
Method oral gavage
Cell Lines Japanese white rabbits
Concentrations 8 mg/kg·d
Incubation Time 5 days
Results Compared with those in PM group, the rabbits in group BPM showed significantly reduced LTB4 production in the lungs (P < 0.05), up-regulated cAMP/ PKA and Rap1 signaling pathway activities (P < 0.05), and alleviated lung hyper-permeability and inflammation (P < 0.05).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 308.38
Formula C16H24N2O4
CAS Number 58970-76-6
Purity >99%
Solubility DMSO 3 mg/mL
Storage at -20°C
References

[1] Imamura N, et al. Leuk Lymphoma. Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up-and down-regulation of CD13/aminopeptidase N.

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Keywords: Ubenimex, Bestatin supplier, Aminopeptidase, inhibitors

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