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Tyrphostin AG 879

Cat. No. M3098
Tyrphostin AG 879 Structure
Synonym:

AG 879

Size Price Availability Quantity
10mg USD 90 In stock
25mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.

Protocol
Cell Experiment
Cell lines MCF-7 cells
Preparation method Growing cells in 96-well plates which is containing 100 μL medium per well. Ten microliters of MTT solution (5 mg/ml in PBS) is added to each well and incubation continued for 4 h at 37 °C. Subsequently, 100 μL 10% SDS in 0.01 M HCl is added. After incubation at 37°C overnight, absorption is measured at 550 nm in an ELISA reader using a reference filter of 690 nm.
Concentrations 20 μM
Incubation time 46 hours
Animal Experiment
Animal models nude mice carrying v-Ha-RAS transformed NIH 3T3 cells
Formulation 30% dimethyl sulfoxide with PBS
Dosages 20 mg/kg
Administration Intraperitoneally administrated on days 3, 5, 7, 10, 12, 14, and 17.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 316.46
Formula C18H24N2OS
CAS Number 148741-30-4
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tyrphostin AG 879, AG 879 supplier, EGFR/HER2, inhibitors

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