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Tyrphostin AG 825

Cat. No. M8813
Tyrphostin AG 825 Structure
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Biological Activity

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Chemical Information
Molecular Weight 397.47
Formula C19H15N3O3S2
CAS Number 149092-50-2
Solubility (25°C) DMSO: soluble
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Atiqur Rahman, et al. Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

[2] Laura Muoz-Moreno, et al. Stimulation of neuroendocrine differentiation in prostate cancer cells by GHRH and its blockade by GHRH antagonists

[3] JunJun Ling, et al. Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis

[4] Eya Wolfson, et al. Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer

[5] Jn Koval, et al. Degradation of HER2 receptor through hypericin-mediated photodynamic therapy

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