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Tylosin

Cat. No. M10205
Tylosin Structure
Synonym:

Tylosin A; Fradizine; Tylocine; Tylosine

Size Price Availability Quantity
50mg USD 70  USD70 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tylosin is a macrolide antibiotic obtained from cultures of Streptomyces fradiae.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 916.1
Formula C46H77NO17
CAS Number 1401-69-0
Purity >98%
Solubility DMSO ≥ 30 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Carlo Pinna, et al. Animals (Basel). In Vitro Evaluation of the Effects of Tylosin on the Composition and Metabolism of Canine Fecal Microbiota

[2] Ayse Er, et al. Acta Vet Hung. Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice

[3] Mingfu Liu, et al. Proc Natl Acad Sci U S A. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

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Keywords: Tylosin, Tylosin A; Fradizine; Tylocine; Tylosine supplier, Antibiotic, inhibitors

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