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Tylosin

Cat. No. M10205
Tylosin Structure
Synonym:

Tylosin A; Fradizine; Tylocine; Tylosine

Size Price Availability Quantity
50mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Tylosin is a macrolide antibiotic obtained from cultures of Streptomyces fradiae.

Chemical Information
Molecular Weight 916.1
Formula C46H77NO17
CAS Number 1401-69-0
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Carlo Pinna, et al. Animals (Basel). In Vitro Evaluation of the Effects of Tylosin on the Composition and Metabolism of Canine Fecal Microbiota

[2] Ayse Er, et al. Acta Vet Hung. Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice

[3] Mingfu Liu, et al. Proc Natl Acad Sci U S A. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

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  Catalog
Abmole Inhibitor Catalog




Keywords: Tylosin, Tylosin A; Fradizine; Tylocine; Tylosine supplier, Antibiotic, inhibitors, activators


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