Free shipping on all orders over $ 500

TVB-3664

Cat. No. M10175
TVB-3664 Structure
Synonym:

TVB3664

Size Price Availability Quantity
2mg USD 240  USD240 In stock
10mg USD 690  USD690 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression. TVB-3664 combined with taxane treatment enhances inhibition of in vitro tumor cell growth compared to treatmentwith either agent alone. In lung, ovarian, prostate, and pancreatic tumor xenograft studies, TVB-3664 and paclitaxel or docetaxel combine to inhibit xenograft tumor growth with significantly enhanced anti-tumor activity.

Protocol
Cell Experiment
Cell lines Calu-6 cells, A549 cells
Preparation method Calu-6 cells are treated with 50 nM TVB-3664 for 48 h. Paclitaxel is added to the cell culture media to a final concentration of 6 nM. After the 2 h of incubation with paclitaxel, cells and supernatant are collected for analysis.
Concentrations 50 nM
Incubation time 48 h, 72 h
Animal Experiment
Animal models female BALB-c-nude mice
Formulation formulated at 3-V Biosciences in 100% PEG-400 and diluted with water to a final PEG concentration of 30% immediately before dosing for oral dosing
Dosages 10 mg/kg, 2.5 mg/kg
Administration PO, IV
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 468.47
Formula C25H23F3N4O2
CAS Number 2097262-58-1
Purity >99%
Solubility DMSO 85 mg/mL
Storage at -20°C
References

[1] Yekaterina Y Zaytseva, et al. Oncotarget. Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

[2] Timothy S Heuer, et al. EBioMedicine. FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

Related FAS Products
GLPG0974

GLPG0974 is a potent and selective FFA2 (also called GPR43) antagonist.

Triheptanoin

Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator.

AP1903 (Rimiducid)

Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended

Fatostatin

Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.

C75 trans

C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: TVB-3664, TVB3664 supplier, FAS, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.