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Tulobuterol

Cat. No. M13900
Tulobuterol Structure
Synonym:

C-78 free base

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 227.73
Formula
CAS Number 41570-61-0
Purity >99%
Solubility DMSO 90 mg/mL
Storage 2-8°C, protect from light
References

[1] Ayumi Iwanami, et al. [Effect of Storage of Tulobuterol Tapes after Package Opening and Liner Peeling on Their Formulation Properties]

[2] Shujuan Luo, et al. Sustained release of tulobuterol from graphene oxide laden hydrogel to manage asthma

[3] Lixia Fu, et al. Tulobuterol patch alleviates allergic asthmic inflammation by blockade of Syk and NF-κB activation in mice

[4] Yuichi Takizawa, et al. Skin permeability of tulobuterol in two transdermal formulations and their followability

[5] Gen Tamura, et al. Transdermal tulobuterol patch, a long-actingβ(2)-agonist

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Keywords: Tulobuterol, C-78 free base supplier, Adrenergic Receptor, inhibitors

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