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Tris Dodecyl Sulfate

Cat. No. M9582
Tris Dodecyl Sulfate Structure
Synonym:

LAURYL SULFATE TRIS SALT

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Quality Control & Documentation
Biological Activity

Tris Dodecyl Sulfate

Chemical Information
Molecular Weight 359.48
Formula C10H22O4S.C4H11NO3
CAS Number 50996-85-5
Solubility (25°C) DMSO
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuan Zhang, et al. Major cause of antibody artifact bands on non-reducing SDS-PAGE and methods for minimizing artifacts

[2] Laura Koontz. TCA precipitation

[3] Nan Zhang, et al. Ammonium dodecyl sulfate as an alternative to sodium dodecyl sulfate for protein sample preparation with improved performance in MALDI mass spectrometry

[4] J F Poduslo. Glycoprotein molecular-weight estimation using sodium dodecyl sulfate-pore gradient electrophoresis: comparison of tris-glycine and tris-borate-EDTA buffer systems

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Keywords: Tris Dodecyl Sulfate, LAURYL SULFATE TRIS SALT supplier, inhibitors, activators


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