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Tripelennamine hydrochloride

Cat. No. M3091
Tripelennamine hydrochloride Structure
Synonym:

Pyribenzamine HCl

Size Price Availability Quantity
200mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Tripelennamine is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.

Chemical Information
Molecular Weight 291.82
Formula C16H21N3.HCl
CAS Number 154-69-8
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] E EPSTEIN. Dermatitis occurring during therapy with tripelennamine hydrochloride (pyribenzamine hydrochloride)

[2] W R MACLAREN, et al. A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms

[3] H E BELLRINGER. Tripelennamine (pyribenzamine) idiosyncrasy

[4] S Y Yeh. Potentiation of pentazocine antinociception by tripelennamine in the rat

[5] S Y Yeh, et al. The pharmacokinetics of pentazocine and tripelennamine

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