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Trichloroacetic acid

Cat. No. M13343
Trichloroacetic acid Structure
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1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Trichloroacetic acid (TCA) is derived from trichloroethylene (TCE) metabolism. It can be used as an acid decalcifier. Trichloroacetic acid, a metabolite of Trichloroacetic acid, is believed to contribute to its liver cancer effect in mice.

Chemical Information
Molecular Weight 163.39
Formula C2HCl3O2
CAS Number 76-03-9
Solubility (25°C) Soluble in water, alcohol, ethyl ether, benzene, acetone
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] L Zenjari, et al. J Med Vasc. Trichloroacetic acid (50%) in the treatment of venous leg ulcers

[2] Ahmad Nofal, et al. Dermatol Surg. Trichloroacetic Acid in Different Concentrations: A Promising Treatment Modality for Vitiligo

[3] Wioletta Barańska-Rybak, et al. Dermatol Ther. Trichloroacetic acid peel complicated with impetigo contagious infection

[4] Andrew J Link, et al. Cold Spring Harb Protoc. Trichloroacetic acid (TCA) precipitation of proteins

[5] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Trichloroacetic acid

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