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Trichlormethiazide

Cat. No. M6030
Trichlormethiazide Structure
Size Price Availability Quantity
50mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 380.66
Formula C8H8Cl3N3O4S2
CAS Number 133-67-5
Purity >99%
Solubility 54 mg/mL in DMSO
Storage at -20°C
References

Comparison of Azelnidipine and Trichlormethiazide in Japanese Type 2 Diabetic Patients with Hypertension: The COAT Randomized Controlled Trial.
Takihata M, et al. PLoS One. 2015 May 4;10(5):e0125519. PMID: 25938807.

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Abmole Inhibitor Catalog 2017




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