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Triazolo-pyramidine derivative

Cat. No. M6126
Triazolo-pyramidine derivative  Structure
Size Price Availability Quantity
5mg USD 390 In stock
10mg USD 550 In stock
50mg USD 1680 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Triazolo-pyramidine derivative is a purine receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 407.43
Formula C20H21N7O3
CAS Number 1202402-40-1
Purity >99%
Solubility 125 mg/mL in DMSO
Storage at -20°C
References

Androgen Receptor Antagonists and Anti-Prostate Cancer Activities of Some Newly Synthesized Substituted Fused Pyrazolo-, Triazolo- and Thiazolo-Pyrimidine Derivatives
Bahashwan SA, et al. Int J Mol Sci. 2014 Nov 24;15(11):21587-602. PMID: 25421248.

Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety.
Luo Y, et al. Eur J Med Chem. 2013 Jun;64:54-61. PMID: 23644188.

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