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Triamcinolone Acetonide

Cat. No. M3508
Triamcinolone Acetonide Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Triamcinolone acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone. It is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Triamcinolone reduces the swelling, itching, and redness that can occur in these types of conditions.

Chemical Information
Molecular Weight 434.5
Formula C24H31FO6
CAS Number 76-25-5
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhen Xiang, et al. Int J Biol Sci. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels

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