Tremella polysaccharide is an acidic heteropolysaccharide prepared from the fruit body of Tremella fuciformis Bark (Tremella fuciformis Bark) or submerged culture mycelium and fermentation broth, can be used as adjuvant. It can enhance the immune function of the body, can significantly improve the function of mouse mononuclear macrophage system, increase the number of plaque forming cells (PFC) and the production of hemolysin in normal or immunocompromised animals; promote normal mouse spleen cells or hydrogenation The pine inhibits the ConA-induced lymphocyte proliferation response of mouse spleen cells; enhances the immune function of normal animals or cyclophosphamide-induced delayed allergic reactions in animals; promotes the production of interferon and IL-2.
| CAS Number | 9075-53-0 |
| Solubility (25°C) | Soluble in warmed water |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Dandan Yang, et al. Tremella polysaccharide: The molecular mechanisms of its drug action
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