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Trans-Farnesol

Cat. No. M21465
Trans-Farnesol Structure
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100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Trans-Farnesol is a signaling molecule that is derived from farnesyl diphosphate, an intermediate in the isoprenoid/cholesterol biosynthetic pathway.

Chemical Information
Molecular Weight 222.37
Formula C15H26O
CAS Number 106-28-5
Storage 2-8℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gyllyandeson de Arajo Delmondes, et al. Chem Biol Interact. Possible mechanisms involved in the neuroprotective effect of Trans,trans-farnesol on pilocarpine-induced seizures in mice

[2] Adelaide Fernandes Costa, et al. Med Mycol. Farnesol: An approach on biofilms and nanotechnology

[3] Aline Rogria Freire de Castilho, et al. PLoS One. Trans,trans-farnesol, an antimicrobial natural compound, improves glass ionomer cement properties

[4] Sheida Torabi, et al. Exp Biol Med (Maywood). Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation

[5] Daniel B Raudabaugh, et al. Mycopathologia. Effect of Trans, Trans-Farnesol on Pseudogymnoascus destructans and Several Closely Related Species

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