Trans-crocetin (Croceic Acid) is an NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). Transcrocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS). Transcrocetin at higher concentrations (40-160 µM) reduces significantly cellular viability.
*The compound is unstable in solutions, freshly prepared is recommended
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related NMDA Products|
Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
Dizocilpine (MK-801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
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