Free shipping on all orders over $ 500

Trans-crocetin

Cat. No. M10581
Trans-crocetin Structure
Synonym:

Croceic Acid; Transcrocetin

Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 130  USD130 In stock
25mg USD 250  USD250 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Trans-crocetin (Croceic Acid) is an NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). Transcrocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS). Transcrocetin at higher concentrations (40-160 µM) reduces significantly cellular viability. 

*The compound is unstable in solutions, freshly prepared is recommended

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 328.4
Formula C20H24O4
CAS Number 27876-94-4
Purity >98%
Solubility Water
DMSO
Storage -20°C, sealed
References

[1] Maria Jose Bagur, et al. Molecules. Saffron: An Old Medicinal Plant and a Potential Novel Functional Food

[2] M Lautenschlager, et al. Phytomedicine. Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier

Related NMDA Products
Radiprodil (RGH-896)

Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).

Dizocilpine

Dizocilpine (MK-801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Trans-crocetin, Croceic Acid; Transcrocetin supplier, NMDA, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.