Trans-crocetin (Croceic Acid) is an NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). Transcrocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS). Transcrocetin at higher concentrations (40-160 µM) reduces significantly cellular viability.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 328.4 |
| Formula | C20H24O4 |
| CAS Number | 27876-94-4 |
| Solubility (25°C) | Water DMSO |
| Storage | -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related NMDA Products |
|---|
| Esketamine
Esketamine (ESK) is an NMDA-receptor antagonist. |
| Glypromate
Glypromate (Gly-Pro-Glu) is a neuroactive peptide with a potent action on acetylcholine release. Glypromate (Gly-Pro-Glu) is a weak NMDA receptor agonist binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. |
| Radiprodil (RGH-896)
Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
| L-Glutamic acid monosodium salt hydrate
L-Glutamic acid monosodium salt hydrate is also a Kainate receptor, NMDA receptor and quisqualate receptor agonist; an excitatory amino acid neurotransmitter. |
| Putrescine dihydrochloride
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
