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Tranilast

Cat. No. M6025
Tranilast Structure
Synonym:

MK 341; SB 252218

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 70 In stock
50mg USD 80 In stock
100mg USD 120 In stock
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Quality Control
Biological Activity

Tranilast is an antiallergic agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 327.33
Formula C18H17NO5
CAS Number 53902-12-8
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Inhibitory Effect of Tranilast on Transforming Growth Factor-Beta-Induced Protein in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts.
Kim TI, et al. Cornea. 2015 Aug;34(8):950-8. PMID: 26020822.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tranilast, MK 341; SB 252218 supplier, Angiotensin Receptor, inhibitors

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