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Tosedostat

Cat. No. M2284
Tosedostat Structure
Synonym:

CHR2797

Size Price Availability Quantity
5mg USD 120 In stock
10mg USD 200 In stock
25mg USD 420 In stock
50mg USD 750 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tosedostat (CHR2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, <1000, <5000, <10000 and <30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively. It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 406.47
Formula C21H30N2O6
CAS Number 238750-77-1
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
Related Aminopeptidase Products
Ubenimex

Ubenimex, also known as bestatin, is a competitive protease inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tosedostat, CHR2797 supplier, Aminopeptidase, inhibitors

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