Free shipping on all orders over $ 500

Topiramate

Cat. No. M4950
Topiramate Structure
Synonym:

McN 4853; RWJ 17021

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
200mg USD 120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Topiramate (Topamax) is a structurally novel broad-spectrum antiepileptic compound (AED) with established efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatric patients with generalised tonic-clonic seizures,topiramate has been believed to be a type of antiepileptic compound that blocks spread of seizures.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 339.36
Formula C12H21NO8S
CAS Number 97240-79-4
Purity >99%
Solubility DMSO 68 mg/Ml; Water <1 mg/mL
Storage at -20°C
References

Target pharmacology of topiramate, a new antiepileptic drug.
Nakamura J,et.al. Nihon Yakurigaku Zasshi 2000 Jan;53-7. PMID: 10876816.

Related GluR Products
(+)-MK 801 Maleate

(+)-MK 801 (Maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

JNJ-42153605

JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM.

Lu AF21934

Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.

Beclometasone dipropionate

Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.

ADX-47273

ADX47273 is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Topiramate, McN 4853; RWJ 17021 supplier, GluR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.