Topiramate (Topamax) is a structurally novel broad-spectrum antiepileptic compound (AED) with established efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatric patients with generalised tonic-clonic seizures,topiramate has been believed to be a type of antiepileptic compound that blocks spread of seizures.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 68 mg/Ml
Water <1 mg/mL
Target pharmacology of topiramate, a new antiepileptic drug.
Nakamura J,et.al. Nihon Yakurigaku Zasshi 2000 Jan;53-7. PMID: 10876816.
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