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Tolnaftate

Cat. No. M6023
Tolnaftate Structure
Size Price Availability Quantity
100mg USD 60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 307.41
Formula C19H17NOS
CAS Number 2398-96-1
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo.
Kezutyte T, et al. Acta Pol Pharm. 2011 Nov-Dec;68(6):965-73. PMID: 22125963.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tolnaftate supplier, inhibitors

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