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Toceranib

Cat. No. M5342
Toceranib Structure
Synonym:

su-11654; pha-291639

Size Price Availability Quantity
10mg USD 185 In stock
50mg USD 480 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Toceranib(SU 11654; PHA 291639) is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 396.46
Formula C22H25FN4O2
CAS Number 356068-94-5
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

Maintenance therapy with toceranib following doxorubicin-based chemotherapy for canine splenic hemangiosarcoma.
Gardner HL, et al. BMC Vet Res. 2015 Jun 11;11:131. PMID: 26062540.

Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study.
London CA, et al. PLoS One. 2015 Apr 29;10(4):e0124889. PMID: 25923466.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Toceranib, su-11654; pha-291639 supplier, VEGFR/PDGFR, inhibitors

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