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TMRM

Cat. No. M11524
TMRM Structure
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Biological Activity

Tetramethylrhodamine methyl ester (TMRM) is a cell permeable, cationic fluorescent dye with a maximum excitation/emission wavelength of 550nm/576nm. It emits red fluorescence and can easily adsorb active mitochondria. Store in refrigerator (-5 to -30°C) away from light.

Chemical Information
Molecular Weight 401.48
Formula C25H25N2O3+
CAS Number 115532-49-5
Solubility (25°C) N/A
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Honglin Mei, et al. J Cell Mol Med. Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity

[2] Lorena Fernandez-Mosquera, et al. Autophagy. Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

[3] Sarah Creed, et al. Methods Mol Biol. Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM)

[4] Fredrik Wallberg, et al. Cold Spring Harb Protoc. Analysis of Apoptosis and Necroptosis by Fluorescence-Activated Cell Sorting

[5] Brad Chazotte. Cold Spring Harb Protoc. Labeling mitochondria with MitoTracker dyes

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