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TMA-DPH

Cat. No. M11517
TMA-DPH Structure
Size Price Availability
1mg USD 98  USD98 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tma-dph contains a cationic trimethylammonium substitute that can be used as a surface anchor locator to improve the localization of the fluorescent probe DPH in the membrane. The maximum excitation/emission wavelength is 355nm/430nm, and it is blue fluorescent and stored at room temperature away from light.

*The compound is unstable in solutions, freshly prepared is recommended

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 461.62
Formula C28H31NO3S
CAS Number 115534-33-3
Purity >98%
Solubility N/A
Storage -20°C , protect from light , dry , sealed
References

[1] Antnio M T M do Canto, et al. Biochim Biophys Acta. Diphenylhexatriene membrane probes DPH and TMA-DPH: A comparative molecular dynamics simulation study

[2] Brad Chazotte. Cold Spring Harb Protoc. Labeling the plasma membrane with TMA-DPH

[3] C Saldanha, et al. J Membr Biol. Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation

[4] G Ferretti, et al. Membr Biochem. Properties of a phosphatidylcholine derivative of diphenyl hexatriene (DPH-PC) in lymphocyte membranes. A comparison with DPH and the cationic derivative TMA-DPH using static and dynamic fluorescence

[5] A Benedetti, et al. J Gastroenterol Hepatol. Plasma membrane fluidity in isolated rat hepatocytes: comparative study using DPH and TMA-DPH as fluorescent probes

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