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Tizanidine HCl

Cat. No. M6019
Tizanidine HCl Structure
Size Price Availability Quantity
50mg USD 90 In stock
100mg USD 125 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 290.17
Formula C9H9Cl2N5S
CAS Number 64461-82-1
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test.
Ouyang H, et al. Pain Res Manag. 2015 Nov-Dec;20(6):321-6. PMID: 26357686.

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  Catalog
Abmole Inhibitor Catalog 2017




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