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Tirofiban hydrochloride monohydrate

Cat. No. M6018
Tirofiban hydrochloride monohydrate Structure
Size Price Availability Quantity
5mg USD 50 In stock
10mg USD 75 In stock
50mg USD 280 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 495.07
Formula C22H39ClN2O6S
CAS Number 150915-40-5
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

High-bolus dose tirofiban compared with abciximab in primary percutaneous coronary intervention: a propensity score-matched outcome study.
Austin D, et al. EuroIntervention. 2015 Feb;10(10):1187-94. PMID: 24831494.

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  Catalog
Abmole Inhibitor Catalog 2017




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