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Tildipirosin

Cat. No. M6134

Tildipirosin Structure
Size Price Availability Quantity
5mg USD 350 In stock
10mg USD 500 In stock
50mg USD 1500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Results indicated that metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevented subsequent culture of the pathogen from bronchial secretions and was more effective in minimizing clinical disease and lung lesions than was metaphylactic administration of tulathromycin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 734.02
Formula C41H71N3O8
CAS Number 328898-40-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni five days after metaphylactic administration of tildipirosin or tulathromycin.
Confer AW, et al. Am J Vet Res. 2016 Apr;77(4):358-66. PMID: 27027834.

Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.
Poehlsgaard J, et al. ACS Chem Biol. 2012 Aug 17;7(8):1351-5. PMID: 22563863.

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  Catalog
Abmole Inhibitor Catalog 2017




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