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Tideglusib

Cat. No. M2306
Tideglusib Structure
Synonym:

NP-12; NP031112

Size Price Availability Quantity
10mg USD 85 In stock
50mg USD 145 In stock
100mg USD 270 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM.

Customer Product Validations & Biological Datas
Source Nat Cell Biol (2016). Figure 7. Tideglusib
Method immunoblotting
Cell Lines GSC11 cells
Concentrations 2.5 μM or 5 μM
Incubation Time 36 h
Results Tideglusib was reported to increase the level of phosphorylated GSK3β-S9, which was also found in GSC11 cells
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 334.39
Formula C19H14N2O2S
CAS Number 865854-05-3
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tideglusib, NP-12; NP031112 supplier, GSK-3, inhibitors

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