Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Source||Nat Cell Biol (2016). Figure 7. Tideglusib|
|Cell Lines||GSC11 cells|
|Concentrations||2.5 μM or 5 μM|
|Incubation Time||36 h|
|Results||Tideglusib was reported to increase the level of phosphorylated GSK3β-S9, which was also found in GSC11 cells|
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