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Thonningianin A

Cat. No. M10672
Thonningianin A Structure
Size Price Availability Quantity
2mg USD 85  USD85 In stock
5mg USD 148  USD148 In stock
10mg USD 235  USD235 In stock
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Quality Control & Documentation
Biological Activity

Thonningianin A is an ellagitannin with anti-cancer activities. Thonningianin A also has antioxidant properties of radical scavenging, anti-superoxide formation and metal chelation. Thonningianin A effectively inhibited the proliferation of HepG-2 cells by inducing apoptosis.

Chemical Information
Molecular Weight 874.71
Formula C42H34O21
CAS Number 271579-11-4
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qian Liu, et al. Pharm Biol. Quantification of thonningianin a in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study

[2] Luca Pompermaier, et al. J Sep Sci. Purification of thonningianins A and B and four further derivatives from Thonningia sanguinea by one- and two-dimensional centrifugal partition chromatography

[3] Tian-Tian Zhang, et al. Food Funct. Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG-2 human hepatocellular carcinoma cells

[4] Maxwell Afari Gyamfi, et al. Food Chem Toxicol. Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro

[5] Maxwell Afari Gyamfi, et al. Biochem Pharmacol. Antioxidant properties of Thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea

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