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Thio-TEPA

Cat. No. M6008
Thio-TEPA Structure
Synonym:

Thiotepa

Size Price Availability Quantity
25mg USD 85  USD85 In stock
50mg USD 130  USD130 In stock
100mg USD 215  USD215 In stock
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Quality Control & Documentation
Biological Activity

Thio-TEPA(Thioplex; Tiofosfamid) is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate.

Chemical Information
Molecular Weight 189.22
Formula C6H12N3PS
CAS Number 52-24-4
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hagen B, et al. Cancer Chemother Pharmacol. Pharmacokinetics of thio-TEPA and TEPA in the conventional dose-range and its correlation to myelosuppressive effects.

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Keywords: Thio-TEPA, Thiotepa supplier, DNA Alkylator/Crosslinker, inhibitors, activators


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