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Thiazole Orange

Cat. No. M13802
Thiazole Orange Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Thiazole orange is an unsymmetrical cyanine dye which can be conjugated to oligonucleotides (ONs) to create fluorogenic hybridisation probes. Thiazole orange can be used for reticulocyte analysis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 476.61
Formula
CAS Number 107091-89-4
Purity >99%
Solubility
Storage 2-8°C, protect from light, dry, sealed
References

[1] Lingling Zhang, et al. ACS Appl Bio Mater. Thiazole Orange Styryl Derivatives as Fluorescent Probes for G-Quadruplex DNA

[2] Tadao Takada, et al. Chembiochem. Stacked Thiazole Orange Dyes in DNA Capable of Switching Emissive Behavior in Response to Structural Transitions

[3] Ohad Suss, et al. Molecules. Broad Applications of Thiazole Orange in Fluorescent Sensing of Biomolecules and Ions

[4] Rajesh Kumar Gautam, et al. Spectrochim Acta A Mol Biomol Spectrosc. Photophysics of thiazole orange in deep eutectic solvents

[5] Ahmed Abdelhameed, et al. Bioorg Med Chem Lett. Synthesis and antileishmanial evaluation of thiazole orange analogs

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