Tetracycline hydrochloride is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic. Tetracycline binds to the 30S subunit of microbial ribosomes. Tetracycline inhibits protein synthesis by blocking the attachment of charged aminoacyl-tRNA. Thus tetracycline prevents introduction of new amino acids to the nascent peptide chain. The action is usually inhibitory and reversible upon withdrawal of the drug. Resistance to the tetracycline results from changes in permeability of the microbial cell envelope. In susceptible cells, the tetracycline is concentrated from the environment and does not readily leave the cell. Tetracycline hydrochloride is used in the treatment of bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 90 mg/mL warmed|
Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.
Chatzispyrou IA, et al. Cancer Res. 2015 Nov 1;75(21):4446-9. PMID: 26475870.
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