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Tenuazonic acid

Cat. No. M10543
Tenuazonic acid Structure
Size Price Availability Quantity
5mg USD 600  USD600 In stock
10mg USD 1080  USD1080 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 197.23
Formula C10H15NO3
CAS Number 610-88-8
Purity >98%
Solubility
Storage 2-8°C, dry, sealed
References

[1] Takeshi Kashiwa, et al. Biosci Biotechnol Biochem. Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae

[2] Jiale Shi, et al. Cells. Tenuazonic Acid-Triggered Cell Death Is the Essential Prerequisite for Alternaria alternata (Fr.) Keissler to Infect Successfully Host Ageratina adenophora

[3] Viviana Poliseno, et al. Biomolecules. Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents

[4] Shiguo Chen, et al. Pestic Biochem Physiol. Recent advances in tenuazonic acid as a potential herbicide

[5] David Siegel, et al. Acta Crystallogr Sect E Struct Rep Online. Deacetyl- tenuazonic acid

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