TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
Cell Experiment | |
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Cell lines | HL60 |
Preparation method | After 96 h exposure of the cells to the drug,assessing the antiproliferative effect of Tempol by the MTT assay . Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM). |
Concentrations | 0.05–1.6 mM |
Incubation time | 96 h |
Animal Experiment | |
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Animal models | Male Wistar rats |
Formulation | Saline |
Dosages | 30 mg/kg |
Administration | bolus injection |
Molecular Weight | 172.24 |
Formula | C9H18NO2 |
CAS Number | 2226-96-2 |
Solubility (25°C) | DMSO 20 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Neslihan Pinar. Effects of Tempol on Epileptic Activity in Picrotoxin-Induced Epilepsy in Rats
[5] Tlio de Almeida Hermes, et al. Tempol improves redox status in mdx dystrophic diaphragm muscle
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