Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Molecular Weight | 417.46 |
Formula | C20H27N5O5 |
CAS Number | 189188-57-6 |
Purity | >98% |
Solubility | 35 mg/mL in DMSO |
Storage | at -20°C |
The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations.
Higgins DL, et al. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan;385(1):103-9. PMID: 21901313.
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