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Tegaserod maleate

Cat. No. M5992
Tegaserod maleate Structure
Size Price Availability Quantity
10mg USD 115 In stock
50mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 417.46
Formula C20H27N5O5
CAS Number 189188-57-6
Purity >98%
Solubility 35 mg/mL in DMSO
Storage at -20°C
References

The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations.
Higgins DL, et al. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan;385(1):103-9. PMID: 21901313.

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  Catalog
Abmole Inhibitor Catalog 2017




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