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Tedizolid

Cat. No. M19871
Tedizolid Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
25mg USD 260  USD260 In stock
50mg USD 380  USD380 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 370.34
Formula C17H15FN6O3
CAS Number 856866-72-3
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] M Salavert Llet, et al. Rev Esp Quimioter. Tedizolid: new data and experiences for clinical practice

[2] No authors listed. Tedizolid

[3] Ronald G Hall 2nd, et al. Expert Opin Pharmacother. An evaluation of tedizolid for the treatment of MRSA infections

[4] No authors listed. Tedizolid

[5] Erica Yookyung Lee, et al. Antimicrob Agents Chemother. Thrombocytopenia with Tedizolid and Linezolid

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