TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
| Molecular Weight | 306.72 |
| CAS Number | 243966-09-8 |
| Solubility (25°C) | 0.1 M NaOH 6.67 mg/mL (ultrasonic and adjust pH to 9 with NaOH) |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Mahdi Al Dhafiri, et al. Topical Steroid Damaged Face: A Cross-Sectional Study from Saudi Arabia
[3] Tanja Makazlieva, et al. Prognostic factors in thyroid carcinomas: a 17-year outcome study
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