Tat-beclin 1, a Beclin 1-derived peptide, is an effective inducer of autophagy and can stimulate autophagy by mobilizing endogenous Beclin 1. It also reduced in vitro accumulation of polyglutamine amplified protein aggregates and replication of multiple pathogens, including HIV-1, and reduced mortality in mice infected with chikungunya disease (CHIKV) or West Nile virus (WNV).
Sequence：Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr
| Molecular Weight | 3741.10 |
| Formula | C164H251N57O45 |
| CAS Number | 1423821-88-8 |
| Solubility (25°C) | Water ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Biji Mathew, et al. Autophagy. Autophagy and post-ischemic conditioning in retinal ischemia
[5] Yuxiao Sun, et al. Circulation. Beclin-1-Dependent Autophagy Protects the Heart During Sepsis
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