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Targocil

Cat. No. M9305
Targocil Structure
Size Price Availability Quantity
2mg USD 145  USD145 In stock
5mg USD 183  USD183 In stock
10mg USD 270  USD270 In stock
25mg USD 610  USD610 In stock
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Quality Control & Documentation
Biological Activity

Targocil shows excellent activity against S. aureus isolates from suspected cases of bacterial keratitis, including both MSSA and MRSA isolates, with MICs that range from 1 to 2 μg/mL.

Chemical Information
Molecular Weight 475.95
Formula C21H22ClN5O4S
CAS Number 1200443-21-5
Solubility (25°C) DMSO: ≥ 21 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Suzuki T, et al. Antimicrob Agents Chemother. In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates.

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