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Taprenepag

Cat. No. M9854
Taprenepag Structure
Synonym:

CP-544326

Size Price Availability Quantity
5mg USD 153  USD170 In stock
10mg USD 225  USD250 In stock
25mg USD 450  USD500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Taprenepag, also known as CP-544326, is a potent and selective EP(2) receptor agonist, with IC50 values of 10 and 15 nM for human and rat EP2, respectively. Taprenepag (CP-544326) increases cAMP levels in HEK293 cells expressing human EP2 (EC50=2.8 nM). Taprenepag is the active metabolite of PF-04217329.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 478.52
Formula C24H22N4O5S
CAS Number 752187-80-7
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma
Ganesh Prasanna, et al. Exp Eye Res. 2011 Sep;93(3):256-64. PMID: 21376717.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Taprenepag, CP-544326 supplier, Prostaglandin Receptor, inhibitors

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