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Tandospirone

Cat. No. M5989
Tandospirone Structure
Size Price Availability Quantity
10mg USD 100 In stock
50mg USD 450 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tandospirone(SM-3997) is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 383.49
Formula C21H29N5O2
CAS Number 87760-53-0
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets.
Baba S, et al. Behav Brain Res. 2015;287:120-6. PMID: 25804359.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tandospirone supplier, 5-HT Receptor, inhibitors

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