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TA 02

Cat. No. M6146
TA 02 Structure
Size Price Availability Quantity
5mg USD 380 In stock
10mg USD 550 In stock
50mg USD 1680 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. IC50 value: 20 nM. TA-02 is a novel compound with similar cardiogenic properties as SB203580 and SB202190. TA-02 especially inhibits TGFBR-2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 333.33
Formula C20H13F2N3
CAS Number 1784751-19-4
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling.
Laco F, et al. J Mol Cell Cardiol. 2015 Mar;80:56-70. PMID: 25528965.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TA 02 supplier, p38 MAPK, inhibitors

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