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Sucrose acetate isobutyrate

Cat. No. M11478
Sucrose acetate isobutyrate Structure
Synonym:

SAIB

Size Price Availability Quantity
500g USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Its a high purity liquid fatty acid sucrose ester, is also a surfactant.

Chemical Information
Molecular Weight 454.42
Formula 454.42
CAS Number 34482-63-8
Solubility (25°C) N/A
Storage RT
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sogra F Barakh Ali, et al. AAPS PharmSciTech. Development of Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate

[2] Sathish Dharani, et al. J Pharm Sci. Development of Methamphetamine Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate

[3] Hanmei Li, et al. Curr Drug Deliv. Sucrose Acetate Isobutyrate as an In situ Forming Implant for Sustained Release of Local Anesthetics

[4] R C Reynolds. Food Chem Toxicol. Metabolism and pharmacokinetics of sucrose acetate isobutyrate (SAIB) and sucrose octaisobutyrate (SOIB) in rats, dogs, monkeys or humans: a review

[5] R C Reynolds, et al. Food Chem Toxicol. Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988

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Keywords: Sucrose acetate isobutyrate, SAIB supplier, inhibitors, activators


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