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Sucrose acetate isobutyrate

Cat. No. M11478
Sucrose acetate isobutyrate Structure
Synonym:

SAIB

Size Price Availability Quantity
500g USD 200  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Its a high purity liquid fatty acid sucrose ester, is also a surfactant.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 454.42
Formula 454.42
CAS Number 34482-63-8
Purity >98%
Solubility N/A
Storage RT
References

[1] Sogra F Barakh Ali, et al. AAPS PharmSciTech. Development of Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate

[2] Sathish Dharani, et al. J Pharm Sci. Development of Methamphetamine Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate

[3] Hanmei Li, et al. Curr Drug Deliv. Sucrose Acetate Isobutyrate as an In situ Forming Implant for Sustained Release of Local Anesthetics

[4] R C Reynolds. Food Chem Toxicol. Metabolism and pharmacokinetics of sucrose acetate isobutyrate (SAIB) and sucrose octaisobutyrate (SOIB) in rats, dogs, monkeys or humans: a review

[5] R C Reynolds, et al. Food Chem Toxicol. Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988

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